If any of these events does not happen or is disrupted, infertility will result. About 35% to 40% of infertility cases are due to female infertility, but male infertility is a factor in 40%. Therefore, before you have a lot of testing and treatment, your partner should have a semen analysis done to make sure his sperm is normal. Even if it is abnormal, many treatments are available.
Providing a home for a growing embryo and fetus, the uterus also plays a starring role in reproduction. When fertility problems affect the uterus, surgery can help to restore your fertility. Uterine surgery can correct blockages and abnormal tissue growth, removing scar tissue and fibroids. Surgery can also help repair an abnormally shaped uterus. Some women are born with, or develop, an irregularly shaped uterus, including the following:
Ovulation can be predicted by using an ovulation predictor kit and can be confirmed by a blood test to check the woman’s progesterone level on day 21 of her menstrual cycle. Although several tests exist to evaluate a woman’s ovarian function, no single test is a perfect predictor of fertility. The most commonly used markers of ovarian function include follicle stimulating hormone (FSH) value on day 3 to 5 of the menstrual cycle, anti-müllerian hormone value (AMH), and antral follicle count (AFC) using a transvaginal ultrasound.

Male infertility may be treated with medical, surgical, or assisted reproductive therapies depending on the underlying cause. Medical and surgical therapies are usually managed by an urologist who specializes in infertility. A reproductive endocrinologist may offer intrauterine inseminations (IUIs) or in vitro fertilization (IVF) to help overcome male factor infertility.

Many infertile women tend to cope with immense stress and social stigma behind their condition, which can lead to considerable mental distress.[71] The long-term stress involved in attempting to conceive a child and the social pressures behind giving birth can lead to emotional distress that may manifest as mental disease.[72] Women who suffer from infertility might deal with psychological stressors such as denial, anger, grief, guilt, and depression.[73] There can be considerable social shaming that can lead to intense feelings of sadness and frustration that potentially contribute to depression and suicide.[69] The implications behind infertility bear huge consequences for the mental health of an infertile woman because of the social pressures and personal grief behind being unable to bear children.
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Tobacco smoking is harmful to the ovaries, and the degree of damage is dependent upon the amount and length of time a woman smokes or is exposed to a smoke-filled environment. Nicotine and other harmful chemicals in cigarettes interfere with the body’s ability to create estrogen, a hormone that regulates folliculogenesis and ovulation. Also, cigarette smoking interferes with folliculogenesis, embryo transport, endometrial receptivity, endometrial angiogenesis, uterine blood flow and the uterine myometrium.[8] Some damage is irreversible, but stopping smoking can prevent further damage.[9][10] Smokers are 60% more likely to be infertile than non-smokers.[11] Smoking reduces the chances of IVF producing a live birth by 34% and increases the risk of an IVF pregnancy miscarrying by 30%.[11] Also, female smokers have an earlier onset of menopause by approximately 1–4 years.[12]
Oral drugs used to stimulate ovulation include clomiphene citrate and aromatase inhibitors. While taking these drugs, you will be monitored to see if and when ovulation occurs. This can be done by tracking your menstrual cycle or with an ovulation-predictor kit (an at-home urine test). You may be asked to visit your doctor for a blood test or ultrasound exam.