Chemotherapy poses a high risk of infertility. Chemotherapies with high risk of infertility include procarbazine and other alkylating drugs such as cyclophosphamide, ifosfamide, busulfan, melphalan, chlorambucil and chlormethine. Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and carboplatin. On the other hand, therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, antibiotics such as bleomycin and dactinomycin and antimetabolites such as methotrexate, mercaptopurine and 5-fluorouracil.
Our bodies are created to eat healthy and be active each and every day, but so many of us don’t even come close to this normal existence. If you want to become pregnant, it’s vital, yet often overlooked, to engage in regular exercise in order to get your hormones in proper order — or in other words balanced. From the release of the egg to the condition of the sperm and its ability to reach and fertilize the egg, hormones play a role in just about every process when it comes to conception.
According to the International Chiropractic Pediatric Association, research shows that any misalignment in the spinal column can impact nerve impulses. When it comes to infertility, blocked neurological signals can seriously impact the pituitary as well as hypothalamus, creating problems with hormone balances that often lead to infertility problems. It’s vital to have a healthy spine in order to have a healthy reproductive system. (11)
Psychological infertility (asexuality) in women: A woman who psychologically doesn’t accept the fact that she is a woman or she should become a mother is asexual. While this may not be infertility entirely but apparently it is. Such women experience miscarriages repeatedly. It is essential for the mind and body to work in synchronization and only then harmony exists within the body.
In certain patients, blastocyst culturing allows optimal selection of embryos for transfer and an increased implant rate. However, this technology may not necessarily increase your chance for pregnancy. The main advantage is that fewer embryos may be transferred to eliminate the possibility of triplet and quadruplet pregnancies, while maintaining a high pregnancy rate.
Improper function of the hypothalamus and pituitary glands. The hypothalamus and pituitary glands in the brain produce hormones that maintain normal ovarian function. Production of too much of the hormone prolactin by the pituitary gland (often as the result of a benign pituitary gland tumor), or improper function of the hypothalamus or pituitary gland, may cause a woman not to ovulate.
The effect of infertility can lead to social shaming from internal and social norms surrounding pregnancy, which affects women around the world. When pregnancy is considered such an important event in life, and considered a “socially unacceptable condition”, it can lead to a search for treatment in the form of traditional healers and expensive Western treatments. The limited access to treatment in many areas can lead to extreme and sometimes illegal acts in order to produce a child.
A 2018 study published by JAMA Internal Medicine conducted a diet assessment analysis of 325 women who received fertility treatments. This diet assessment analyzed the concentrated amount of pesticide found on the fruits and vegetables the women ingested. The main outcome from this study highlighted that the women who received fertility treatments and ingested fruits and vegetables with higher concentrations of pesticides were 18 percent less likely to have successful clinical pregnancies and 26 less likely to have live births. (13)
If you need female infertility treatment to get pregnant, your doctor may suggest that you use a donor egg, donor sperm or a donor embryo to have a baby. If you are not producing healthy eggs you may also consider using a surrogate. This is a woman who provides the egg(s) to be fertilized by your partner’s sperm and then she carries the baby to term. With these female infertility treatments, it’s important to have legal representation. If you have healthy eggs but are unable to carry a baby to term, ask your doctor about a gestational carrier. With this female infertility treatment, your partner’s sperm will be used to fertilize your egg(s) outside of your uterus. Then, the healthy embryos will be transferred to the gestational carrier. Again, legal representation is necessary.
Letrozole (Femara ®*) is a medication that is frequently used off-label to cause ovulation. It works by temporarily lowering a woman’s progesterone level, which causes the brain to naturally make more FSH. It is often used to induce ovulation in woman with PCOS, and in women with normal ovulation to increase the number of mature eggs produced in the ovaries.
Cinnamon is one of the best remedies for dealing with infertility in women. It not only improves ovarian functioning but also combats other conditions that lead to infertility, such as Polycystic ovary syndrome (PCOS), endometriosis and uterine fibroids. Cinnamon also regulates the menstrual cycle and improves your fertility in a simple and easy way. For this remedy, take a cup of hot water and add a teaspoon of powdered cinnamon to it. Mix well and drink this solution once every day.
Oral drugs used to stimulate ovulation include clomiphene citrate and aromatase inhibitors. While taking these drugs, you will be monitored to see if and when ovulation occurs. This can be done by tracking your menstrual cycle or with an ovulation-predictor kit (an at-home urine test). You may be asked to visit your doctor for a blood test or ultrasound exam.
Intra-uterine insemination (IUI), also known as artificial insemination, is the process of preparing and delivering sperm so that a highly concentrated amount of active motile sperm is placed directly through the cervix into the uterus. The current IUI pregnancy rate per treatment at UCSF Medical Center is 14 to 15 percent. It can be performed with or without fertility drugs for the female patient.
Ovulation problems are often caused by polycystic ovarian syndrome (PCOS). PCOS is a hormone imbalance problem which can interfere with normal ovulation. PCOS is the most common cause of female infertility. Primary ovarian insufficiency (POI) is another cause of ovulation problems. POI occurs when a woman's ovaries stop working normally before she is 40. POI is not the same as early menopause.
For a woman, testing begins with a medical history and physical exam, including a pelvic exam. The doctor then makes sure that she ovulates regularly and that her ovaries are releasing the eggs. Blood tests are taken to measure hormone levels. The ovaries and uterus may be examined by ultrasound, and a specific X-ray test can check the uterus and fallopian tubes.